Repress cancer growth and sensitize cancer cells to DNA damage therapy
Inhibition of poly (ADP-ribose) glycohydrolase (PARG) enzyme
PARG is an enzyme that plays a key role in DNA damage repair and in the transformation of normal cells to cancer cells, promoting their growth and invasive capability.
PARG is elevated in cancers of the breast, lungs, prostate, and acute lymphoblastic leukemia.
The inhibition of PARG aims to repress cancer growth and to sensitize cancer cells to DNA damage therapy