Treatment of pain related to neuropathic pain
Osteoarthritis (OA) pain
Visceral pain / chronic pancreatitis
Potent, reversible, selective, and orally available vanilloid receptor-1 (TrpV1) ion channel antagonist
NEO6860 is a potent and selective inhibitor at the human TrpV1 channel for capsaicin stimulation.
It does not affect channel activation by either pH or heat.
In primate DRG neurons, NEO6860 blocks only the capsaicin-, not heat-, evoked currents. It does not increase heat thresholds of primate unmyelinated C-fibres.
NEO6860 has successfully completed the GLP IND-enabling toxicology package, which included 28-day rat and primate toxicology studies. In the 28-day primate study, NEO6860 did not affect body temperature.
Phase I clinical trial – SAD completed
Phase II PoC-Clinical Proof of Concept